How Long Does Acyclovir Stay In Your Body?

How is acyclovir eliminated from the body?

Acyclovir is eliminated from the body primarily by urinary excretion of unchanged drug.

Renal clearance of acyclovir (C/r) is usually two to three times greater than glomerular filtration, indicating that a tubular secretory mechanism plays an important role in the drug’s renal elimination..

Is hair loss from acyclovir permanent?

Drug-induced alopecia occurs as a consequence of a toxic effect of the drug on the hair follicle matrix… in rare cases, alopecia may be permanent (1).” Those who use acyclovir due to its “ease of administration” (See the American Journal of Therapeutics, from March 22, 2013) (2), should consider this side effect.

Is acyclovir toxic?

Acyclovir is used therapeutically to treat herpes simplex, cytomegalovirus, Epstein-Barr, and varicella-Zoster. Although acyclovir is thought to be low in toxicity, it has caused an obstructive nephropathy from accumulation of crystals in renal tissue.

Can you develop resistance to acyclovir?

Acyclovir resistance is not common but does occur at higher rates in immunocompromised patients. Acyclovir resistance can be attributed to thymidine kinase mutations and confers cross-resistance among the antiviral nucleoside analogs (acyclovir, valacyclovir, famciclovir, and penciclovir).

Is acyclovir hard on the kidneys?

Abstract. Acute kidney injury is an unfortunate complication of acyclovir therapy secondary to crystal-induced nephropathy. It is characterized by a decrease in renal function that develops within 24–48 hours of acyclovir administration indicated by a rapid rise in the serum creatinine.

What happens if you take too much acyclovir?

But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects. If you take too much: You could have dangerous levels of the drug in your body and experience more severe side effects.

How long does it take for acyclovir to work?

May take up to two hours to reach peak plasma concentrations after oral acyclovir administration. May take up to three days for symptom reduction; however, acyclovir should be taken until the course prescribed is completed. Acyclovir works best when started within 48 hours of symptom onset.

Can you take acyclovir long term?

Nevertheless, we conclude that the use of oral acyclovir for more than 12 months provides substantial additional prevention against recurrence of ocular HSV. Our data suggest that long-term oral acyclovir use remains effective in decreasing the number of recurrences beyond 12 months.

What happens if I stop taking acyclovir?

If you stop taking acyclovir too soon or skip doses, your infection may not be completely treated or may become more difficult to treat.

Does acyclovir weaken immune system?

This medication may rarely cause a life-threatening disorder that affects the blood cells, kidneys, and other parts of the body. This disorder is more likely to occur if you have conditions related to a weakened immune system (such as HIV disease, bone marrow transplant, kidney transplant).

Does acyclovir speed up healing?

It can speed up healing of the sores and decrease symptoms (such as tingling, pain, burning, itching). Acyclovir belongs to a class of medications known as antivirals. It works by stopping the growth of the virus. This medication does not cure herpes, and it does not prevent passing the infection to someone else.

What are the long term side effects of acyclovir?

Other acyclovir side effects, adverse reactions, or health problems may include:Abdominal pain.Aggression.Agitation.Anemia (low iron in the blood)Ataxia (a condition that causes the loss of control over body movement)Coma.Confusion.Diarrhea.More items…