What happens when B cells are activated?
B-cells are activated by the binding of antigen to receptors on its cell surface which causes the cell to divide and proliferate.
Some stimulated B-cells become plasma cells, which secrete antibodies.
Others become long-lived memory B-cells which can be stimulated at a later time to differentiate into plasma cells..
What is a role of activated B cells?
B cells are activated when their B cell receptor (BCR) binds to either soluble or membrane bound antigen. This activates the BCR to form microclusters and trigger downstream signalling cascades. … Cytokines produced by T cells and other cells are important in determining what isotype the B cells express.
What are the two main functions of B cells?
The main functions of B cells are:to make antibodies against antigens,to perform the role of antigen-presenting cells (APCs),to develop into memory B cells after activation by antigen interaction.
What happens when a cell is activated?
Helper T cells become activated when they are presented with peptide antigens by MHC class II molecules, which are expressed on the surface of antigen-presenting cells (APCs). Once activated, they divide rapidly and secrete cytokines that regulate or assist the immune response.
Where does B cell activation occur?
B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. After B cells mature in the bone marrow, they migrate through the blood to SLOs, which receive a constant supply of antigen through circulating lymph.
What happens after a lymphocyte becomes activated?
Lymphocyte activation occurs when lymphocytes (B cells or T cells) are triggered through antigen-specific receptors on their cell surface. For example, activated B cells can give rise to antibody-producing cells and some activated T cells become cytotoxic T cells. …